Our team is a multidisciplinary UK national alliance of doctors who are collaborating with researchers in America and Europe.
Dr Ramesh Bulusu - Our Clinical Lead
Consultant Clinical Oncologist MD, MRCP, MSc, FRCR (Oncology)
Dr Bulusu is the alliance lead and one of the national experts on gastrointestinal stromal tumours (GIST). Working with other specialists in this area, he has developed the national guidelines for the management of this tumour and has lectured, presented and published extensively on the subject.
He is actively involved in numerous clinical trials as a principal and co investigator and has been the consultant clinical lead for PAWS-GIST since its inception in November 2010.
Professor Ian Judson
Consultant Medical Oncologist - FRCP, Royal College of Physicians, London - MD, University of Cambridge - BA (Hons), Natural Sciences, Univesity of Cambridge - MB, BChir,, University of Cambridge
Professor Judson has specialised in the management of sarcomas for the past 20 years and has made a particular study of gastrointestinal stromal tumours (GIST). He was a principal investigator in the Phase I/II trial of imatinib for GIST in 2000/1 and has been actively involved in research into the treatment of this disease since that time.
Dr Michael Leahy
Consultant Clinical Oncologist - BSc (Hons), MBBS, PhD, FRCP
Dr Michael Leahy attended medical school in London and trained in oncology at the Royal London Hospital and St Bartholomew's before completing his specialist training at The Christie, Manchester, in 1998. He spent six years at the University of Leeds as senior lecturer in medical oncology and is now based in Manchester as a medical oncologist on the supra-regional sarcoma and testicular cancer multi-disciplinary teams. Dr Leahy has worked with the PAWS-GIST Alliance since its inception.
Dr Newton Wong
Consultant Histopathologist - BSc MRCP , MBChB, FRCPath, MD
Areas of interest:
- Molecular diagnostics;
- Gastrointestinal pathology;
Emeritus Professor Andrew Hall
- Director, Northern Institute for Cancer Research
- Director, Newcastle Biomedicine Biobank
- Designated Individual for Human Tissue Act Research Licence for Newcastle University
- Professor of Experimental Haematology
- Honorary Consultant Haematologist, Newcastle upon Tyne NHS Foundation Trust
- Pathology Lead, NCRI Confederation of Cancer Biobanks
Professor Hall has been instrumental in setting up of the National GIST tumour bank.
Dr Nicholas Carroll
Consultant Radiologist and Endoscopist, Addenbrooke's Hospital NHS Trust, Cambridge
Special clinical interests: Gastro-intestinal imaging and Endoscopic Ultrasound
- Member of the European Society of Gastro-intestinal and Abdominal Imaging
- Fellow of the Royal College of Radiologists
- Pioneered the development and use of EUS in the eastern region of the UK and currently secretary of the national EUS body.
Mr Richard Hardwick
Specialist Upper Gastro-Intestinal Tract Surgeon
Specialist upper gastro-intestinal tract surgeon with an interest in keyhole and hiatus hernia surgery and gastric and oesophageal cancer. Lead clinician for upper GI cancer at the Cambridge Oesophago-Gastric Centre, which he co-founded in 2001, lead for the National Oesophago-Gastric Cancer Audit and past chairman of the Association of Upper GI Surgeons Audit and Clinical Services Committee. Research interests include early diagnosis of upper GI cancer, Barrett's oesophagus and hereditary forms of stomach cancer. A vociferous campaigner for improved NHS resources.
Dr Phillippe Tanniere
Consultant in Histopathology
Dr Phillippe Tanniere Consultant in Histopathology at the Queen Elizabeth Hospital and Honorary Senior Lecturer at the Medical School, Birmingham, with a special interest in gastro-intestinal and pancreatico-biliary pathology.
Dr Denise Williams
Consultant Paediatric Oncologist - MB Bch (Wales) FRCP FRCPCH
Dr Denise Williams is a specialist in children's cancer care and manages all types of solid tumours as well as working closely with haematology colleagues in the management of children with leukaemia. Her main clinical and research interest is in lymphomas in children and she chairs the European Intergroup Collaboration for paediatric non-Hodgkins Lymphoma (EICNHL).
Dr Palma Dileo
Dr Palma Dileo is Consultant Medical Oncologist on the Sarcoma Unit at University College Hospital, UCLH NHS Trust, specialising exclusively in the management (chemotherapy and radiotherapy) of soft tissue and bone sarcomas. The Sarcoma Unit at UCLH, together with the Sarcoma Unit at the Royal National Orthopaedic Hospital, is the London Sarcoma Service (www.londonsarcoma.org) which offers a comprehensive clinical service to patients of all ages with sarcoma at all sites of the body. She has continued to provide patient care since 1996 (general oncology), with more emphasis on sarcoma and rare tumors starting from 1998. She completed her training at the Istituto Nazionale Tumori of Milan, Italy and at Dana-Farber Cancer Institute, Boston, USA. From 2006 to 2010 she has been Associate Physician, Medical Oncology, Istituto Nazionale Tumori, Milan working in the Sarcoma Team. She has a strong interest in early phase clinical trials and is a co-investigator for a number of clinical trials in sarcoma. She is a member of the EORTC Soft Tissue and Bone Sarcoma Group and ASCO.
Professor Eamonn Maher
Eamonn Maher is Professor of Medical Genetics and Genomic Medicine and Head of the Department of Medical Genetics. Prior to taking up this post in 2013 he was Professor of Medical Genetics and Academic Lead for the Centre for Rare Diseases and Personalised Medicine at the University of Birmingham. Eamonn has published around 400 research papers in scientific journals as well as reviews and book chapters in the fields of cancer genetics, human developmental genetics, epigenetics and genomic imprinting. He has a particular interest in research training for clinician and non-clinician scientists and had supervised more than 25 PhD or MD students to completion. Current research in Eamonn’s group relates to the molecular basis of inherited forms of renal cell carcinoma (supported by an ERC Advanced Researcher Award 2013-2018), phaeochromocytoma, multiple primary cancers, genomic imprinting disorders (www.ingenium-itn.eu) and developmental disorders.
Dr Robin Jones
Dr Robin Jones is a medical oncologist specialising in the treatment of bone and soft tissue sarcomas. He has experience in conducting Phase I, II and III trials, as well translational studies in sarcoma. He trained in medical oncology at the Royal Marsden Hospital and between 2010 and 2014 he was Head of the Sarcoma Program at the University of Washington / Fred Hutchinson Cancer Research Center in Seattle. His main research interest focuses on clinical trials of novel agents and immunotherapy in sarcoma.
Dr Charlotte Benson
Dr Charlotte Benson is a Consultant Medical Oncologist working at the Royal Marsden Hospital Sarcoma unit. She specialises solely in the treatment of Soft tissue Sarcoma and GIST. She is active in research and is a member of the EORTC Soft Tissue Sarcoma and Bone group and the NCRI Sarcoma CSG.
Dr Olivier Giger - MD, PhD, University Lecturer and Honorary NHS Consultant
Dr Giger completed his me dical and speciality training in Switzerland and was awarded an MD at the Univeristy of Zurich. He received a PhD from the University of Liverpool for his research on epigenetic changes in the tumour stroma. He is now a University Lecturer and Honorary Consultant in Molecular- and Histopathology working in the Department of Pathology and the Haematopathology & Oncology Diagnostic Service (HODS) at Addenbrookes’ University Hospital in Cambridge.His area of expertise lies in gastrointestinal pathology and molecular pathology of solid tumours. His research interests include the tumourmicroenvironment, gastrointestinal stromal tumours and colorectal cancer. He also enjoys teaching undergraduate and postgraduate students.
Dr Ruth Casey MB BCH BAO, FRCPI
Dr Casey is a consultant post in Endocrinology at Cambridge University NHS Foundation Trust. Dr Casey has a specialist clinical interest in hereditary endocrine neoplasia and endocrine cancer. Her research has focused mainly on the role of succinate dehydrogenase gene mutations in tumorigenesis and has a strong translational focus. Her interest in succinate dehydrogenase deficient tumours has led to her collaboration with PAWS-GIST.
Dr Henry Daebritz
Dr Däbritz currently works as a Clinical Research Scientist at the Cancer Metabolism Research Unit, CRUK Beatson Institute, Glasgow. His research focusses on tumours with tricarboxylic acid cycle enzyme dysfunction and on identification of metabolic biomarkers of cancer. This research led to his collaboration with PAWS-GIST.
Mr Myles Smith
Consultant Surgical Oncologist & General Surgeon MB BCh BAO (NUIG, Ireland), PhD (UCC, Ireland, FRCSI
Mr Smith works in the Sarcoma Unit and Skin Unit at The Royal Marsden. He has a special interest in surgery for soft tissue sarcomas such as GIST and an interest in the application of minimally invasive surgery to the management of rare cancers such as PAWS-GIST.
Dr Karen Sisley
Dr Sisley is a Senior Lecturer in the Department of Oncology & Metabolism, The Medical School, Sheffield, Her research interests include investigating the genetic characterization of sarcoma and developing a molecular pathological classification suitable for all subtypes.sarcomas. Karen has established the Rare Tumour Research Group (RTRG) to allow cross fertilization of ideas and the development of strong working associations supporting all researchers working with her and has been working with the PAWS-GIST team deriving, maintaining and characterising cell lines from biopsies of PAWS-GIST.
Dr Fiona McRonald
Dr McRonald is a scientist who works for Public Health England. Fiona and colleagues at the National Cancer Registration and Analysis Service (NCRAS) have been working with GIST Support UK for several years to collect and record detailed data on molecular tests carried out by NHS labs on GISTs. Linking this data to cancer registration records will give a full picture of mutational status in tumours; this will help to identify and characterise the ever increasing subtypes of GIST and PAWS-GIST.
Supporting / Associate Bodies & Individuals
- GIST Support UK:
Life President - Judith Robinson, Chair - Nic Puntis
- SPAEN - Sarcoma Patients Euronet:
Roger Wilson & Marcus Wartenburg
- Paediatric & Wild-type GIST Clinic NIH Washington USA:
Dr Lee Henman - Pediatric Oncologist, Scientific Director of Clinical Washington DC
- SDH deficient GIST Consortium
PAWS-GIST Patient Director, Vice Chair & Trustee GIST Support UK: Jayne Bressington
Patron: Charlie Hamilton James
Wildlife Photographer and television presenter
Fundraising, Social Media & Trustee GIST Support UK: Dr Victoria Bassett